Table 1.
Patient characteristics
| N | % | |||
|---|---|---|---|---|
| Age | Median (months) | 36 | ||
| Range (months) | 13-216 | |||
| Gender | Male | 35 | 60 | |
| Female | 23 | 40 | ||
| Site of Metastasis | Bone/Bone Marrow/Lymph node | 48 | 83 | |
| Lymph node alone | 3 | 5 | ||
| Others | 7 | 12 | ||
| Primary Sites | Retroperitoneal | 12 | 21 | |
| Adrenal Gland | 41 | 71 | ||
| Thorax | 5 | 8 | ||
| MYCN | Amplified | 19 | 34 | |
| (available for 56 pt) | Non amplified or MYCN gain | 37 | 66 | |
| Induction CT | ICE/CECAT | 21 | 36 | |
| Topo NB | 37 | 64 | ||
| Primary Tumor Reduction before Surgery* | <50% | 4 | 8 | |
| >50%, <95% | 34 | 68 | ||
| >95% | 12 | 24 | ||
| Surgery | Radical | 45 | 78 | |
| Not Radical | 13 | 22 | ||
| Response before HDC** | CR/VGPR | 21 | 37 | |
| PD | 11 | 20 | ||
| PR | 24 | 43 | ||
| RT | Yes | 28 | 48 | |
| No | 30 | 52 |
LEGEND: pt, patient; BX, biopsy; CR, complete remission; VGPR, very good partial remission; PD, progressive disease; PR, partial response. For “others” site of metastasis was considered Bone or/and Bone Marrow or/and Lymph node plus lung or/and liver metastatis.
*In 7 patients surgery was performed at diagnosis, one patient died for an acute bleeding after accidental removal of central vein catheter.
**Two patients were not considered for this analysis; one patient died for acute bleeding and the later one died for acute renal failure.