Table 3.
Univariate analysis of factors predictive for Local PFS
| Pts | Local PFS | 95% CI | Univariate analysis | ||
|---|---|---|---|---|---|
| % | Pvalue | ||||
| Age | 12-18 months | 11 | 100 | - | 0.04 |
| >18 months | 47 | 63 | 42-76 | ||
| Site of Metastasis | Bone /Bone Marrow/ Lymph-node | 48 | 75 | 56-86 | 0.07 |
| Lymph-node alone | 3 | 100 | - | ||
| Others | 7 | 27 | 1-69 | ||
| Primary Sites | Retroperitoneal | 12 | 59 | 16-86 | 0.50 |
| Adrenal Gland | 41 | 76 | 55-88 | ||
| Thorax | 5 | 60 | 13-88 | ||
| MYCN | Amplified | 19 | 51 | 23-74 | 0.00 |
| (available for 56 pt) | Non-amplified or MYCN gain | 37 | 80 | 59-91 | |
| Inducion CT | ICE/CECAT | 21 | 55 | 28-76 | 0.12 |
| Topo NB | 37 | 83 | 53-93 | ||
| Primary Tumor Reduction before Surgery* | <50% | 35 | 78 | 54-90 | 0.04 |
| >50%, <90% | 4 | 50 | 1-91 | ||
| >90% | 12 | 47 | 17-72 | ||
| Surgery | Radical | 45 | 68 | 49-81 | 0.35 |
| Not Radical | 13 | 90 | 47-99 | ||
| Response before HDC** | CR/VGPR | 21 | 86 | 62-95 | <0.001 |
| PD | 11 | 0 | - | ||
| PR | 24 | 64 | 34-83 | ||
| RT | Yes | 28 | 100 | - | <0.001 |
| No | 30 | 48 | 27-67 |
LEGEND: pt, patient; BX, biopsy; CR, complete remission; VGPR, very good partial remission; PD, progressive disease; PR, partial response.
*In 7 patients surgery was performed at diagnosis, one patient died for an acute bleeding after accidental removal of central vein catheter.
**Two patients were not considered for this analysis; one patient died for acute bleeding and the later one died for acute renal failure.