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. 2015 Feb 13;15:12. doi: 10.1186/s12890-015-0009-z

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© Sweeney et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Concentration-dependent IP ₃ accumulation responses to bradykinin in ASM cells derived from asthmatic and non-asthmatic donors. (A) Representative examples of bradykinin concentration-response curves obtained for ASM cell monolayers from one asthmatic (○) and one non-asthmatic (▼) donor. (B) Graph showing the bradykinin concentrations causing a 50% of the maximal IP₃ accumulation (shown as –log EC₅₀ (M) values) in normal (n = 8) and asthmatic (n = 11) ASM donors. (C) The increase in IP₃ accumulation following stimulation by a maximally effective concentration of bradykinin (10 μM) for ASM cells from non-asthmatic (n = 8) and asthmatic (n = 11) donors. Symbols key: filled circles: GINA 1–3; open circles: GINA 4–5; filled squares: non-asthmatic donors. Data are shown as mean (SEM) and analyzed by Student’s t-test.