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. Author manuscript; available in PMC: 2015 Mar 4.
Published in final edited form as: Dev Cell. 2013 Dec 19;28(1):19–29. doi: 10.1016/j.devcel.2013.11.012

Figure 1. Structure of Efr3-N.

Figure 1

(A) Ribbons diagram, colored blue to red from N terminus to C terminus.

(B) Conservation in Efr3-N. Orientation at left is as in (A). Surfaces around the N terminus of Efr3-N and in the middle of the rod are highly conserved.

(C) Electrostatic potential. The conserved surface at the N terminus is basic.

(D) Location of mutations mapped onto structure. Residues H67 and R69, which are mutated in Efr3-3 and Efr3-N2, are in the conserved basic patch, but not visible here. Recombinant Efr3-3 is well folded as assessed by CD (Figure S2), but Efr3-4 aggregates in vitro.