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. 2015 Jan 7;11:2. doi: 10.1186/1744-8069-11-2

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© Nasirinezhad et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Behavioral outcome of early and late injection of lentiviral constructs. Tactile allodynia in the von Frey test (A), cold allodynia in the acetone test (B), thermal hyperalgesia in the plantar test (C) and mechanical hyperalgesia in the Randall-Selitto test (D) in SCI rats after viral injection encoding endomorphins + SHG injected at early (two weeks, n = 10) or late (6 weeks, n = 12) time points after SCI. Values are expressed as the ± S.E.M. There were no statistical differences observed between early and late SHG-EM injections comparing the data up to 7 weeks post injection, with the exception of week 5, when the threshold for mechanical allodynia was significantly higher in the group injected early post SCI. *p < 0.05.