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. 2015 Feb 28;16:8. doi: 10.1186/s12858-015-0037-6

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© Rosti et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The GAS1 family sequence alignment. A) The sequences start from the beginning of the mature human GAS1 and numbered according to the human amino acid numbering. Residues over ca. 85% conserved (11/13) are coloured with a black-to-grey scale, in higher vertebrates (mammals) there is an extended loop in the N-terminal domain around residues 80–100 (human GAS1 numbering). The C-termini are poorly conserved (residues beyond 250), note the RGD sequence at 306–308. B) Conserved surface features on GAS1 displayed on the N-terminal domain. C) Conserved surface features on GAS1 displayed on the C-terminal domain; conserved sites in B and C are coloured in red (with >75% sequence similarity, see text).