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. 2015 Feb 28;16:8. doi: 10.1186/s12858-015-0037-6

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© Rosti et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Binding of human GAS1 to RET. A) A binding curve of GAS1 to ecRET. Purified human GAS1 shows clear ligand independent binding to ecRET. Binding was measured with a concentration series of 2 μM, 4 μM, 8 μM and 16 μM, 24 μM and 32 μM. The dissociation constant (K _d) was obtained based on the equilibrium (R _eq) values at different concentration from two independent experiments with a K _d = 12.2 ± 8.2. B) The biacore sensograms for GAS1 binding (in response units, RU) to RET at different concentrations (as above).