Figure 10.

The hypothetical interaction of Orai -CMBD to CaM- N and CaM -C. The residues of Leu73, Trp76, and Leu79 are major contributors to the binding of CaM. In the Trp76 vicinity, the residues in one letter abbreviation in CaM-C are from the crystal structure while those in CaM-N are a hypothetical prediction (A). The alteration in the position and chimeras are shown in parenthesis. Leu79 is located in the forming helix and interacts with hydrophobic residues (B). Note that the numbering of residues is one residue off from Figure 1 since the first Met residue is not included in the crystal structure. We used the same numbering convention as the reference in this figure and within the text for clarity.