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. 2014 Dec 19;14:195. doi: 10.1186/1471-2261-14-195

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© Wu et al.; licensee BioMed Central. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Stimulation of calcineurin-NFAT, p-MEK5-MEK5, and p-ERK5-ERK5 activation promote eccentric left ventricular hypertrophy in aging and aged SHS exposure. (A). Protein expression levels of calcineurin, NFAT, p-NFAT, p-MEK5, MEK5, p-ERK5 and ERK5 in the MYC, MYS, MOC and MOS groups were measured by western blotting analysis. (B). Statistical analysis of calcineurin densitometry and NFAT/p-NFAT, p-MEK5/MEK5, and p-ERK5/ERK5 ratios in MYC, MYS, MOC and MOS groups. All data are presented as means ± SD. *p < 0.05, **p < 0.01 significant statistical differences compared with male young control (MYC).