Table 2.

Adjusted Hazard Ratios (HR) of various characteristics on the occurrence of ADRs, HIV Patients on ART, South Africa 2007-2012

	1 st ADR	1 st ADR → 2 nd ADR	Marginal model	Frailty model
Characteristic	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)
Gender
Male	1	1	1	1
Female	1.13 (0.82, 1.55)	1.32 (0.72, 2.42)	1.23 (0.88, 1.72)	1.23 (0.94, 1.62)
Age
30 and less	1	1	1	1
31 – 37	1.33 (0.81, 2.19)	2.41 (0.54, 10.69)	1.59 (0.95, 2.66)	1.51 (0.94, 2.43)
38 – 44	1.83 (1.12, 3.01)*	3.19 (0.73, 13.93)	2.45 (1.47, 4.10)*	2.07 (1.29, 3.32)*
45+	1.43 (0.85, 2.42)	3.23 (0.73, 14.29)	2.02 (1.16, 3.51)*	1.80 (1.11, 2.93)*
Clinic
Clinic A	1	1	1	1
Clinic B	0.77 (0.27, 2.20)	-	0.73 (0.25, 2.11)	0.78 (0.28, 2.22)
Clinic C	3.74 (2.54, 5.50)*	2.36 (0.89, 6.22)	4.03 (2.75, 5.91)*	3.20 (2.24, 4.57)*
Clinic D	1.99 (1.10, 3.58)*	2.76 (0.85, 8.99)	2.14 (1.12, 4.09)*	1.96 (1.18, 3.25)*
ART regimens
1a (d4T, 3TC, EFZ)	1	1	1	1
1b (d4T, 3TC, NVP)	1.01 (0.61, 1.66)	0.65 (0.19, 2.21)	1.08 (0.65, 1.80)	0.99 (0.64, 1.55)
1c (AZT, 3TC, EFZ)	1.86 (1.20, 2.87)*	1.83 (0.91, 3.69)	2.09 (1.35, 3.22)*	1.83 (1.27, 2.62)*
Others	1.00 (0.65, 1.54)	1.18 (0.50; 2.82)	1.35 (0.90, 2.01)	1.43 (0.99, 2.04)
Year started ART
Before 2009	1	1	1	1
2009 and after	0.78 (0.58, 1.06)	0.41 (0.23, 0.74)*	0.55 (0.40, 0.76)*	0.90 (0.70, 1.16)

*Statistically significant at p-value ≤ 0.05.