Table 1.
Chromosomal translocation and fusion proteins in solid tumors involving ALK gene
| Disease | Chromosomal rearrangement | Fusion protein | Frequency (%) | Reference |
|---|---|---|---|---|
| NSCLC | inv(2)(p21;p23) | EML4-ALK | 2-5 | [59,64,65] |
| t(2;3)(p23;q21) | TFG-ALK | 2 | [65] | |
| t(2;10)(p23;p11) | KIF5B-ALK | <1 | [53,57] | |
| t(2;14)(p23;q32) | KLC1-ALK | <5 | [55] | |
| t(2;9)(p23;q31) | PTPN3-ALK | ND | [50] | |
| IMT | t(1;2)(q25;p23) | TPM3-ALK | 0.5 | [24] |
| t(2;19)(p23;p13) | TPM4-ALK | <5 | [24] | |
| t(2;17)(p23;q23) | CLTC-ALK | <5 | [40,42,43] | |
| inv(2)(p23;q35) | ALK-ATIC | <5 | [32] | |
| t(2;11;2)(p23;p15;q31) | CARS-ALK | <5 | [34,35] | |
| t(2;2)(p23;q13) | RANBP2-ALK | <5 | [36] | |
| inv(2)(p23;p15;q31) | RANBP2-ALK | <5 | [38] | |
| t(2;4)(p23;q21) | SEC31L1-ALK | <5 | [52] | |
| BC | inv(2)(p21;p23) | EML4-ALK | <5 | [64] |
| CRC | inv(2)(p21;p23) | EML4-ALK | <5 | [64] |
| t(2;2)(p23.3) | C2orf44-ALK | <5 | [51] | |
| ESCC | t(2;19)(p23;p13) | TPM4-ALK | ND | [27,28] |
| RCC | t(2;10)(p23;q22) | VCL-ALK | ND | [47] |
| t(1;2)(q25;p23) | TPM3–ALK | ND | [23] | |
| inv(2)(p21;p23) | EML4–ALK | ND | [23] |
NSCLC; non small cell lung cancer, IMT; inflammatory myofibroblastic tumor, BC; breast cancer, CRC; colorectal cancer, ESCC; esophageal squamous cell carcinoma, RCC; renal cell carcinoma, ND; not determined.