Table 2.

MTX intolerance development

Time point	N	Intolerance, n(%) a
3 months	140b	22 (15.7)
6 months	137b	33 (24.1)
12 months	129b	30 (23.3)
First treatment year	142	59 (41.5)
6 or 12 monthsd	152c	51 (33.6)

Abbreviations: MTX, methotrexate; n, number of patients.

^aFrequencies are based on observed data_; ^bPatients still on MTX; ^cCohort for prediction model construction; ^dOutcome was imputed in 21.7% of cases.