Table 7. Multivariate Cox proportional hazards regression analysis for CV events.
| Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | Model 6 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR 95% CI | P | HR 95% CI | P | HR 95% CI | P | HR 95% CI | P | HR 95% CI | P | HR 95% CI | P | |
| Echocardiographic data | ||||||||||||
| LVEF | 0.95 (0.92–0.99) | 0.007 | ||||||||||
| E/E’ | 1.05 (1.02–1.09) | 0.003 | ||||||||||
| LAVI | 1.02 (1.00–1.03) | 0.012 | ||||||||||
| E/E’ > 15 | 5.40 (2.73–10.70) | <0.001 | ||||||||||
| LAVI > 32 | 5.56 (2.28–13.59) | <0.001 | ||||||||||
| E/E’>15, LAVI>32 | 5.96 (3.09–11.51) | <0.001 | ||||||||||
| Clinical and laboratory data | ||||||||||||
| Age | 1.00 (0.98–1.03) | 0.843 | 0.99 (0.97–1.02) | 0.998 | 0.99 (0.98–1.02) | 0.909 | 0.99 (0.97–1.02) | 0.657 | 0.99 (0.97–1.02) | 0.742 | 0.99 (0.97–1.02) | 0.997 |
| Sex(male) | 0.99 (0.56–1.77) | 0.997 | 1.16(0.63–2.11) | 0.636 | 1.07 (0.59–1.94) | 0.836 | 1.48 (0.79–2.77) | 0.218 | 1.00 (0.56–1.80) | 0.998 | 1.27 (0.69–2.33) | 0.437 |
| Dialysis modality (HD) | 1.44 (0.61–3.39) | 0.404 | 1.36(0.59–3.15) | 0.474 | 1.36 (0.59–3.15) | 0.474 | 1.69(0.73–3.91) | 0.225 | 1.56 (0.67–3.66) | 0.306 | 1.58 (0.68–3.68) | 0.285 |
| Smoking (Yes) | 0.87 (0.40–1.91) | 0.730 | 0.94 (0.42–2.11) | 0.873 | 0.71 (0.32–1.58) | 0.395 | 1.18 (0.51–2.77) | 0.701 | 0.69 (0.31–1.51) | 0.353 | 1.05 (0.45–2.44) | 0.914 |
| DM | 0.96 (0.51–1.98) | 0.911 | 0.95(0.50–1.80) | 0.880 | 1.06 (0.57–1.96) | 0.860 | 0.93 (0.49–1.80) | 0.838 | 0.85(0.45–1.61) | 0.613 | 0.82 (0.42–1.58) | 0.543 |
| CAD | 1.71 (0.79–3.70) | 0.170 | 1.76 (0.81–3.80) | 0.154 | 2.26 (1.08–4.71) | 0.03 | 1.09 (0.49–2.35) | 0.825 | 1.70 (0.80–3.63) | 0.169 | 1.05 (0.49–2.24) | 0.913 |
| CVD | 2.23 (1.10–4.45) | 0.027 | 1.99 (0.97–4.08) | 0.062 | 1.94 (0.96–3.89) | 0.063 | 2.45 (1.15–5.22) | 0.021 | 2.60 (1.26–5.39) | 0.010 | 2.77 (1.34–5.73) | 0.006 |
| Arrhythmia | 2.77 (1.10–7.00) | 0.031 | 1.57 (0.61–4.04) | 0.351 | 1.04 (0.34–3.16) | 0.396 | 2.17 (0.86–5.45) | 0.1 | 1.47 (0.59–3.69) | 0.407 | 2.00 (0.79–5.05) | 0.142 |
| Hb | 1.02 (0.99–1.05) | 0.097 | 0.99 (0.97–1.03) | 0.955 | 1.01 (0.99–1.04) | 0.396 | 1.00 (0.98–1.03) | 0.881 | 1.01 (0.98–1.03) | 0.541 | 0.93 (0.98–1.03) | 0.928 |
| Albumin | 0.51 (0.30–0.90) | 0.017 | 0.58 (0.34–0.99) | 0.047 | 0.43 (0.25–0.74) | 0.002 | 0.68 (0.40–1.16) | 0.153 | 0.41 (0.23–0.72) | 0.002 | 0.52 (0.30–0.90) | 0.019 |
| 24-hr Urine volume | 0.99 (0.99–1.00) | 0.003 | 0.99 (0.99–0.99) | 0.001 | 0.99 (0.99–1.00) | 0.009 | 0.99 (0.99–1.00) | 0.001 | 0.99 (0.99–1.00) | 0.009 | 0.99 (0.99–1.00) | <0.001 |
CV, cardiovascular; HR, hazard ratio; CI, confidential interval; LVEF, left ventricular ejection fraction; LAVI, left atrial volume index; DM, diabetes mellitus; CAD, coronary arterial disease; CVD, cerebrovascular disease; Hb, hemoglobin.