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. 2015 Mar 4;10(3):e0119181. doi: 10.1371/journal.pone.0119181

Fig 2. Kaplan–Meier analyses of 5-year disease free survival (DFS) and 5-year overall survival (OS) in 227 patients with HCC.

Fig 2

(A and B) The HCCs with CA-IX protein expression correlated with significantly lower DFS and OS than the HCCs without CA-IX protein expression (P = 0.0001 and P<1x10-6, respectively). (C and D) The combinatorial analyses revealed that CA-IX-positive high-stage HCCs had the lowest DFS (P<1 x10-6) and OF (P<1x10-6), which were lower than CA-IX negative high-stage HCCs (P = 0.0004 and P<1x10-6, respectively). However, there were no differences concerning both DFS and OS in low-stage HCCs regardless presence or absence of CA-IX expression. (E and F) The female patients presenting with high-stage HCCs exhibited the lowest DFS (P<1 x 10-6) and OS (P<1x10-6), which were lower than male patients presenting with high-stage HCCs (P = 0.0214 and P = 0.0188, respectively). However, there were no differences concerning DFS and OS in male and female patients with low-stage HCCs. (+): The presence of CA-IX protein expression. (-): The absence of CA-IX expression.