Table 1. Univariate analysis of CA-IX protein expression with various clinical and pathological features in 227 patients with surgically resectable primary hepatocellular carcinoma.
| CA-IX protein expression | ||||
|---|---|---|---|---|
| Variables | Yes n (%) | No n (%) | Odds Ratio (range) | p value |
| Age | ||||
| >56 | 57 (52) | 76 (65) | 1.72 | 0.0446 |
| ≤56 | 53 (48) | 41 (35) | (0.98–3.04) | |
| Gender | ||||
| Male | 77 (70) | 100 (85) | 2.52 | 0.0049 |
| Female | 33 (30) | 17 (15) | (1.25–5.13) | |
| HBsAg | ||||
| Negative | 34 (31) | 48 (41) | 1.55 | 0.1128 |
| Positive | 76 (69) | 69 (59) | (0.87–2.79) | |
| Anti-HCV | ||||
| Negative | 77 (70) | 75 (64) | 1.31 | 0.3451 |
| Positive | 33 (30) | 42 (36) | (0.72–2.37) | |
| Cirrhosis | ||||
| No | 71 (65) | 71 (61) | 1.18 | 0.5480 |
| Yes | 39 (35) | 46 (39) | (0.66–2.10) | |
| μ-fetoprotein (ng/ml) | ||||
| ≤ 200 | 48 (44) | 91 (78) | 4.52 | <1x10-6 |
| >200 | 62 (56) | 26 (22) | (2.45–8.40) | |
| Tumor size (cm) | ||||
| ≤3 | 21 (19) | 43 (37) | 2.46 | 0.0031 |
| >3 | 89 (81) | 74 (63) | (1.29–4.73) | |
| Tumor grade | ||||
| I-II | 54 (49) | 97 (83) | 5.03 | <1x10-6 |
| III~IV | 56 (51) | 20 (17) | (2.63–9.71) | |
| Tumor stage | ||||
| I | 30 (27) | 69 (59) | 3.83 | 1.5x10-6 |
| II-III | 80 (73) | 48 (41) | (2.11–6.98) | |