Table 1. Functional analysis of Sp1 signature.

Term ID	Term name	p-value	Term size	Overlap size
GO:0044238	Primary metabolic process	1.11e-17	5444	379
GO:0044237	Cellular metabolic process	2.47e-15	5416	369
GO:0019222	Regulation of metabolic process	6.63e-11	3828	268
GO:0045087	Innate immune response	3.84e-08	191	33
GO:0035556	Intracellular signal transduction	2.28e-06	1382	112
GO:0009966	Regulation of signal transduction	4.54e-05	1643	122
GO:0051702	Interaction with symbiont	7.01e-05	39	11
GO:0016043	Cellular component organization	1.00e-04	3338	214
GO:0035458	Cellular response to interferon-beta	1.00e-04	24	6
GO:0034613	Cellular protein localization	2.54e-03	727	62
GO:0006886	Intracellular protein transport	6.96e-03	454	41
GO:0060340	Positive regulation of type I interferon-mediated signaling pathway	7.84e-03	8	5
GO:0044699	Single-organism process	8.63e-03	8909	475
GO:0032606	Type I interferon production	9.86e-03	38	10
GO:0010935	Regulation of macrophage cytokine production	4.33e-02	10	5
GO:0061082	Myeloid leukocyte cyokine production	4.46e-02	16	6

The gene list enrichment analysis from the Gene Ontology of the SP1 specific signature was performed with g:Profiler. The moderate hierarchical filtering used here allows a compact representation of gene list enrichment results. Significantly enriched GO terms containing less than 5 genes were excluded.