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. 2015 Mar 4;10(3):e0118672. doi: 10.1371/journal.pone.0118672

Table 3. Eleven Successfully searched human drug targets(8 for P125, 3 for PN12567) are modulated by 40 unique approved drugs.

Genes DrugBank ID Name TTD ID Disease
PKLR DB00119 Pyruvic acid DAP000543 Dietary shortage
PKM2 DB00119 Pyruvic acid DAP000543 Dietary shortage
MDH2 DB00157 NADH DAP001291 Parkinson's disease
SDHB DB00139 Succinic acid DAP000545 Dietary shortage
PPARG DB00159 Icosapent DAP000969 Hyperglyceridemic
DB00244 Mesalazine DAP000729 Ulcerative colitis
DB00328 Indomethacin DAP000617 Patent ductus arteriosus
DB00412 Rosiglitazone DAP000271 Diabetes mellitus
DB00731 Nateglinide DAP000918 Diabetes mellitus
DB00795 Sulfasalazine DAP000153 Inflammatory bowel dieaseas and rheumatoid arthritis
DB00912 Repaglinide DAP000133 diabetes mellitus
DB00966 Telmisartan DAP000766 diabetes mellitus
DB01014 Balsalazide DAP000733 Inflammatory bowel disease
DB01050 Ibuprofen DAP000780 Pain
DB01067 Glipizide DAP000920 diabetes mellitus
DB01132 Pioglitazone DAP000272 diabetes mellitus
DB01252 Mitiglinide DAP000917 diabetes mellitus
DB01393 Bezafibrate DAP001182 hyperlipidaemia
EGFR DB00072 Trastuzumab DAP000391 breast cancer
DB00281 Lidocaine DAP000121 anesthetic
DB00317 Gefitinib DAP000657 cancers
DB00530 Erlotinib DAP001010 non-small cell lung cancer
DB01259 Tykerb DCL000344 bladder, head & neck, nsclc, brain cancer
JUN DB00570 Vinblastine DAP000785 cancers
DB01029 Irbesartan DAP000364 hypertension
HSP90AA1 DB00615 Rifabutin DAP000656 tuberculosis and mycobacterium avium complex (mac) disease
TYMS DB00293 Raltitrexed DAP000759 colon and rectum cancers
DB00322 Floxuridine/5-fluorouracil DAP001245 colorectal cancer
DB00432 Trifluridine DAP000760 viral infection
DB00440 Trimethoprim DAP000927 urinary tract infections
DB00441 Gemcitabine DAP001246 cancers
DB00544 Fluorouracil DAP000829 cancers
DB00642 LY231514 DCL000320 non-squamous non-small cell lung cancer
DB00650 Leucovorin/5-fluorouracil DAP001244 colon cancer
DB01101 Capecitabine DAP000761 colorectal cancer
HDAC2 DB00227 Lovastatin DAP000551 hypercholesterolemia
DB00277 Theophylline DAP000002 chronic obstructive pulmonary disease
DB01223 Aminophylline DAP000613 bronchial asthma
DB01303 Oxtriphylline DAP000868 cough
DB02546 Vorinostat DAP001082 cutaneous t-cell lymphoma
VCAM1 DB01136 Carvedilol DAP000135 congestive heart failure