Figure 3. Replication of HIV_BaL and HIV_LAV in penile tissue explants and dissemination of the infection by migratory cells.

Figure 3a shows the time course of HIV_BaL replication in tissue explants at days 4 (black bars), 7 (grey net bars), 9 (white bars) and 11 (grey dotted bars) days post infection. Figure 3b and 3c show dissemination of HIV_BaL (Figure 3b) and HIV_LAV (Figure 3c) infection by migratory cells isolated from different tissue explants, folowing 4 (black bars) and 7 (grey net bars) day co-culture with indicator T cells. Data represent the mean p24 ± standard error of the mean of 3 separate donors; each condition was tested in triplicate. P24 levels for uninfected controls and in the samples exposed to AT-2 treated virus were undetectable (data not shown).