Table 4.

Comparison of estimated mean SF-12v2, SIBDQ, and WPAI:SHP Scores (adjusted for age, gender, BMI, and baseline value) at 12-month maintenance phase endpoint for patients with clinically recurrent or non-recurrent symptoms

	Estimated mean (SE) for non-recurrent patients (n = 117)	Estimated mean (SE) for recurrent patients (n = 29)	P a	Effect size (d)
SF-12v2
Physical functioning	53.8 (0.60)	51.3 (1.23)	ns	0.30
Role physical	53.1 (0.66)	49.3 (1.34)	<0.05	0.42
Bodily pain	53.5 (0.76)	47.4 (1.53)	<0.001	0.60
General health	53.2 (0.71)	48.8 (1.43)	<0.01	0.46
Vitality	53.9 (0.75)	48.6 (1.53)	<0.01	0.52
Social functioning	52.8 (0.75)	48.6 (1.51)	<0.05	0.41
Role emotional	52.8 (0.73)	49.0 (1.47)	<0.05	0.39
Mental health	53.6 (0.70)	49.0 (1.43)	<0.01	0.49
SIBDQ
Bowel symptoms	18.3 (0.28)	15.1 (0.58)	<0.001	0.86
Systemic symptoms	10.9 (0.21)	11.0 (0.43)	ns	0.03
Emotional function	17.6 (0.31)	15.8 (0.62)	<0.01	0.46
Social function	13.2 (0.18)	11.8 (0.37)	<0.001	0.58
WPAI:SHP
Absenteeism	2.4 (1.27)	1.5 (2.62)	ns	−0.06
Presenteeism	3.9 (1.70)	16.6 (3.34)	<0.01	0.71
Overall work impairment	6.1 (2.10)	18.6 (4.35)	<0.05	0.55
Activity impairment	7.5 (1.66)	16.7 (3.29)	<0.05	0.43

SF-12v2 12-item Short-Form Health Survey, version 2, SIBDQ Short Inflammatory Bowel Disease Questionnaire, WPAI:SHP Work Productivity and Activity Impairment: Specific Health Problem, BMI body mass index, SE standard error of the estimated mean, ns not statistically significant

^a P values for comparison of means as a function of recurrence status were derived from analysis of covariance models with recurrence status as a between-subjects factor, and patients’ age, gender, BMI, and baseline value on that domain as covariates