The distribution of class IIa HDAC post-translational modifications within ordered and disordered regions. The probability of disorder was determined for each HDAC amino acid sequence using the PrDOS prediction software. Known PTMS are represented as red stars. Regions falling within established HDAC functional domains are shaded: MEF, red; NLS, green; DAC, purple; NES, yellow. A, HDAC4 sequence, B, HDAC5 sequence, C, HDAC7 sequence, D, HDAC9 sequence.