Fig. 6.

Novel network showing importance of ERK1/2 regulation in the urothelium. Red/pink nodes are proteins that are up-regulated in diabetes, whereas dark/light green nodes are molecules that are down-regulated. Enzymes are represented by diamonds, complexes by circles (or concentric circles), kinases by inverted triangles, transcription regulators by ovals, and translation regulators by hexagons. Solid lines with no arrows are representative of interactions, whereas solid lines with arrows represent activation/expression. Dashed lines with arrows are indicative of indirect activation/expression. Data shown is based on peptide quantitation with a p value of < 0.05.