Fig. 3.

Modification co-evolution analysis of cross-talk PTMs. A The demonstration of modification co-evolution with an excerpt of p53 sequence alignment across human, mouse, and rat. Two pairs of cross-talk and noncross-talk PTM sites and their modification co-evolution scores are shown. B Comparing the modification co-evolution scores of the cross-talk, control, distance control, and function control sets. The proportion of PTM pairs in each set with modification co-evolution measure of 1/3, 2/3, and 1 are shown in blue, green, and yellow respectively in the bar plot.