Skip to main content
. 2015 Feb 15;5(5):515–529. doi: 10.7150/thno.10319

Figure 6.

Figure 6

(A-C) Graph demonstrating biological clearance of injected micro- and nanoparticles from circulation, at constant dose of 4 mg of iron per kg of body weight. (A) Graph shows T2 relaxivity values of blood samples at different time points after administration of 2.80 μm MPIO. The clearance half-life was calculated to be 34.91 s (K = 0.019 s-1, Y0 = 92.18 s-1). (B) Scatter plot showing T2 relaxation rates of various concentrations of 2.8 μm MPIO in blood samples. T2 relaxation rate increases linearly with increasing MPIO concentration (R2 = 0.9907). (C) Graph showing T2 relaxivity values of blood samples at different time points after administration of 20 nm NPIO. The clearance half-life for 20 nm NPIO was calculated to be 153.70 min (K = 0.0045 min-1, Y0 = 34.69 s-1). Curves are fitted as one phase exponential decay constrained to plateau at the average naïve blood sample values (baseline; dashed lines).