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. Author manuscript; available in PMC: 2016 Mar 3.
Published in final edited form as: Cell Rep. 2015 Feb 26;10(8):1288–1296. doi: 10.1016/j.celrep.2015.01.054

Figure 2. The C6orf211 protein possesses a SAM-dependent methyltransferase fold.

Figure 2

(A) I-Tasser predicted folds of C6orf211 suggest a SAM-MT fold. (B) Alignment of C6orf211 homologs identified conservation in predicted SAM binding site. (C) Two 180° views of a threaded model of C6orf211 based on 3PT1.pdb structure, central β sheets and α-helices of the SAM-MT core fold are labelled. Conserved active site glutamate 258 and aspartate 291 highlighted as yellow sticks. Structural images were produced using PyMOL (www.pymol.org). See also Figures S1 and S2.