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. 2015 Mar 5;5:8767. doi: 10.1038/srep08767

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(A) The antifungal drug resistance test. Cells grown to the mid-logarithmic phase were 10-fold serially diluted (1 to 10⁴) and spotted on YPD medium containing the indicated concentration of azole drugs (fluconazole: 16 μg/ml; itraconazole: 0.06 μg/mL; and ketoconazole: 0.25 μg/mL) or amphotericin B (1.2 μg/mL), and further incubated at 30°C for the antifungal drug resistance assay. (B) The neighbors of six novel drug resistance genes are enriched for four biological processes: sterol biosynthetic process, response to drug, transmembrane transport, and cell wall organization and biogenesis. The genes for the four enriched processes show high modularity in CryptoNet.