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. 2015 Mar 5;5:8803. doi: 10.1038/srep08803

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The summary point represents the summary sensitivity and specificity, the 95% confidence region represents the 95% confidence intervals of the summary sensitivity and specificity and the 95% prediction region represents the 95% confidence interval of sensitivity and specificity of each individual study included in the analysis. The plot also includes study estimates indicating the sensitivity and specificity estimated using the data from each study separately. The size of the marker is scaled according to the total number in each study.