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. 2015 Mar 5;5:8777. doi: 10.1038/srep08777

Figure 6. Sex-related response of cholesterol homeostasis to dietary fats in absence of hepatocyte Cyp51.

Figure 6

(a) Fold change differences between the LKO and LWT mice in cholesterol homeostasis genes (n = 5) on the high-fat no-cholesterol (HFnC) and high-fat with cholesterol (HFC) diet. Statistically significant changes are marked with an asterisk (*). Color scale represents log2 fold change (FC) differences from −3 to 3. (b) Western blot analysis of cholesterogenic enzymes and cholesterol homeostasis proteins. A representative western blot of GAPDH is presented. (c) Hepatic levels of sterols and campesterol (n = 8–10). Columns represent means and error bars represent SEMs. Uncropped western blots are presented in Supplementary Figure 11. SREBP2i – inactive membrane-bound form; SREBP2a – active nuclear form. * p < 0.05.