. 2015 Mar 5;5:8771. doi: 10.1038/srep08771

Table 2. Some examples of proposed kinetoplastid targets for non-kinases based on homology to mammalian proteins used in historical assay with some examples compounds.

Target class	Potential kinetoplastid target		No. of chemotypes/compounds	Example structures
Target class	Protein	Gene loci^a	No. of chemotypes/compounds	Example structures
Other enzyme	Phosphosdiestearase	LDBPK_181100Tc00.1047053511269.40Tc00.1047053509805.20Tb10.389.0510	3/4	TCMDC-143547 TCMDC-143248
Proteases	Cysteine peptidases A (CBA) or C (CPC)	LDBPK_290860 (CPC)LDBPK_191460 (CBA)Tb927.6.560 (CPC)Tb927.6.960 (precursor)Tb927.6.1020 (precursor)Tc00.1047053510535.100 (CPC)	3/6	TCMDC-143238 TCMDC-143390
Cytochromes	Ferric reductase (cytochrome homology)	LDBPK_301630Tb11.02.1990Tc00.1047053507665.30	5/5	TCMDC-143560 (also a kinase inhibitor scaffold) TCMDC-143603
Cytochromes	Cytochrome P450 andlanosterol 14-alpha-demethylase	LDBPK_270090LDBPK_343110Tb03.27F10.920Tb11.02.4080Tc00.1047053509231.10Tc00.1047053509719.40Tc00.1047053510101.50	24/44	TCMDC-143376 TCMDC-143433