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. 2012 Feb 15;7(5):347–351. doi: 10.3969/j.issn.1673-5374.2012.05.004

Figure 3.

Figure 3

Effect of 50 ng/mL brain-derived neurotrophic factor (BDNF) on 20 μM β-amyloid peptide (Aβ)(25–35)-induced cell apoptosis (western blot analysis).

Aβ(25–35) treatment of PC12 cells decreases Bcl-2 expression (P < 0.05) and increases Bax expression (P < 0.05). BDNF (50 ng/mL) prevents changes induced by Aβ(25–35) (P < 0.05).

Results are expressed as a ratio of control cells. Data are expressed as mean ± SD from three independent experiments performed in duplicate.

aP < 0.05, vs. control group; bP < 0.05, vs. 20 μM Aβ(25–35). Statistical analyses were performed using one-way analysis of variance, followed by the two-tailed Student's t-test.