Figure 5.
Tyrosine kinase receptor (Trk) influence on brain-derived neurotrophic factor (BDNF) inhibition β-amyloid peptide (Aβ)(25–35)-induced cell apoptosis. PC12 cells were treated with Trk inhibitor K252a.
Western blot analysis shows that the effects of BDNF on Aβ(25–35)-induced cell apoptosis are diminished following K252a treatment.
Data are expressed as mean ± SD. Results are expressed as a ratio of control cells. Three independent experiments were performed in duplicate.
aP < 0.05, vs. controls. Statistical analyses were performed using one-way analysis of variance, followed by the two-tailed Student's t-test.