Table 1.

TDF dose reduction strategies

Creatinine clearance	Dosing interval for TDF 300 mg
(or eGFR – CKD-EPI)
>50	Every 24 hrs
30-49	Every 48 hrs*
10-29	Every 72–96 hrs*
Haemodialysis	After dialysis every 7 days or after ~12 hrs of dialysis*

*Consider whether TDF is the appropriate antiviral.