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. 2014 Jul 9;5(24):12621–12634. doi: 10.18632/oncotarget.2181

Figure 6. Normal NK cells are required for better efficacy of therapeutic approach based on neutrophil priming.

Figure 6

(A) Naive mice with or without NK depletion were inoculated with H22 cells. The mice were treated with pCXCL1/pIFN-γ/psTNF-α with or without the injection of NK cells from naive mice. (B, C) pG/pI6-mice were inoculated with H22 cells together with neutrophils from I-PC of pG/pI6-mice and/or purified NK cells from naive mice. (D, E) pG/pI6-mice were inoculated with H22 cells, and then treated with pCXCL1/pIFN-γ/psTNF-α. Purified NK cells from naive mice were injected to the inoculation site as described in Methods. Tumors were dissected and weighed on d11 after inoculation (A, B, D). The survival rate of mice in each group was recorded in parallel experiments (C, E). Data are pooled from four independent experiments with a total of eight mice in each group (A, B, D), or the combination of two independent experiments with a total of twelve mice in each group (C, E). *p < 0.05, **p < 0.01.