Figure 3. The five-miRNA signature was tightly associated with prognosis in both Microarray cohort (n=44) and Validation cohort (n=134) independent of histology type.

Histology types could stratify the anaplastic gliomas into different prognostic subpopulation although the P value is not enough small in both Microarray (A and F).and Validation cohort (K and P). The five-miRNA signature was could stratify the all anaplastic gliomas into two distinct prognostic subpopulation in both Microarray (B and G).and Validation cohort (L and Q). In each histological subtype of anaplastic gliomas (astrocytomas, oligodendrocytomas and oligoastrocytomas), the five-miRNA signature could also be taken as a stable method used for prognosis stratification in both Microarray (C, D, E, H, I and J) and Validation cohort (M, N, O, R, S and T).