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. 2014 Oct 21;5(24):12607–12620. doi: 10.18632/oncotarget.2610

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Copyright: © 2014 Roos et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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MSP (A) and MS-HRM (B) of the MGMT promoter in paired tumors from three patients before and after vemurafenib treatment. U depicts an unmethylated promoter while M depicts a methylated promoter. Fibroblasts served as negative control (unmethylated promoter) and LN229 cells served as positive control (methylated promoter). (C) Microphotographs of paired tumors before and after vemurafenib. MGMT, MSH2, MSH6 and PMS2 protein was detected using immunohistochemistry. Nuclei were stained with TO-PRO-3.