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. 2014 Nov 13;5(24):12820–12834. doi: 10.18632/oncotarget.2667

Figure 1. TAp73 enhances glycolytic flux.

Figure 1

Increased glycolytic flux as suggested by reduced intracellular glucose and concomitant increased lactate and acetyl-CoA. This result suggests that TAp73 expression sustain Warburg effect and might help explaining while its expression is retained in many cancers. The decrease pyruvate levels probably reflect channeling into lactate and acetyl-CoA. Of note, the augmented acetyl-CoA levels may also stem for increased biosynthesis. **p < 0.05; *0.05 < p < 0.1.