Figure 4. Enhanced polyamines biosynthesis induced by TAp73.
Polyamines show a significant increase after 8h of TAp73β induction. Ornithine, putrescine and spermidine are all upregulated. Polyamine expression has been linked to proliferation and polyamine biosynthesis pathway is highly regarded for anticancer therapy. This increase is not maintained at 16h induction and the reason for this is currently unknown. **p < 0.05.