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. 2014 Dec 10;5(24):12528–12542. doi: 10.18632/oncotarget.2985

Figure 2. Exon array analysis is a sensitive tool to identify MYB C-terminal rearrangement status.

Figure 2

A) Illustrations of MYB protein structure and MYB-NFIB fusion events in ACC. DBD, DNA binding domain; TAD, transcriptional activation domain; NRD, negative regulation domain. B) MYB exon intensity plot for 12 ACC tumor samples identifies variable expression of MYB C-terminal exons and validates MYB fusion status. Red line, MYB exon intensities in ACC tumor; Blue line, MYB exon intensities in matched normal tissue; Star depicts two false fusion-positive samples validated by FISH.