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. 2014 Dec 10;5(24):12528–12542. doi: 10.18632/oncotarget.2985

Figure 3. Integrative analysis identifies both MYB-dependent and MYB-independent genes in ACC.

Figure 3

A) Differentially expressed genes with the highest fold change compared to normal in high or low MYB ACC tumors indicate extracellular gene activation. B) The same analysis as panel A was performed on ACC gene expression array data (Affy_HG133) obtained from public GEO database (accession: GSE28996). C) Top scoring genes that are components of extracellular matrix (ECM). MYB binding genes were defined by published ChIP-Seq data. MYB independent targets were defined as genes that were activated in both high and low MYB ACC tumors. D) Integrative analysis of ACC gene signature to recently published ACC mutational sequencing data identifies potential roles of RUNX1 in ACC tumorigenesis. E) Regulation of extracellular gene HAPLN1 by RUNX1.