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Effect of HDAC inhibitors on FXN mRNA levels in neuronal cells. Quantitative RT-PCR analysis of FXN expression in 16-day-old FRDA neurons after 24-h treatment with HDAC inhibitors 109, 136, and 3 at varying concentrations. FXN mRNA levels were normalized to total RNA concentration. Signals from DMSO-treated samples were arbitrarily set to 1. Error bars = SEM of triplicate measurements.
