Fig. 2.

Alcohol dependence as a predictor of reward-related BOLD response. Results were masked for regions in which there was a significant relationship between stressful life events and reward-related BOLD response. Brain images and scatterplots depict significant associations between alcohol dependence and BOLD response in the mPFC during reward anticipation (A) and reward outcome (B). Scatterplots depict average BOLD response across clusters in the mPFC during reward anticipation (MNI coordinates: 16, 48, 20; R² = −0.23) and reward outcome (MNI coordinates: 20, 28, 22; R² = −0.33). SQRT, square-root transformation.