Table 3.
Alcohol dependence at age 20 as a predictor of reward-related BOLD response
| Condition | MNI Coordinates |
Cluster size | t (df = 147) | ||
|---|---|---|---|---|---|
| x | y | z | |||
| Reward Anticipation | |||||
| mPFC (BA 32) | 16 | 48 | 20 | 142 | 3.71 |
| mPFC (BA 10) | −14 | 46 | 20 | 236 | 3.13 |
| mPFC (BA 24) | 0 | 28 | 16 | 86 | 3.08 |
| mPFC (BA 32) | −6 | 46 | 20 | 84 | 2.79 |
| Reward outcome | |||||
| mPFC (BA 32) | 20 | 28 | 22 | 129 | 4.62 |
| With past-year negative life events included as a covariate (df = 146) | |||||
| Reward anticipation | |||||
| mPFC (BA 32) | 12 | 48 | 22 | 66 | 3.12 |
| mPFC (BAs 10, 32) | −8 | 48 | 22 | 85 | 3.06 |
Note: Alpha Sim corrected P < 0.05 for all contrasts. Results were masked for regions in which there was a significant relationship between cumulative stressful life events and reward-related BOLD response. ‘Tobacco use’, ‘neighborhood disadvantage’ and ‘caregiver education’ were included in these analyses as covariates. BA, Brodmann Area; BOLD, blood-oxygen-level-dependent; MNI, Montreal Neurological Institute.