Table 2. Candidate SNPs associated with length of abstinence in the discovery sample (P<0.001).
| SNP | Gene | Minor allele | MAF |
Total sample (N=225) |
Males (N=148) |
||
|---|---|---|---|---|---|---|---|
| HR | P-value | HR | P-value | ||||
| rs2058878 | GRIN2B | A | 0.493 | 0.49 | 0.000046 | 0.41 | 0.00021 |
| rs17035723 | GLRB | A | 0.139 | 2.14 | 0.00012 | 2.88 | 0.000098 |
| rs2160733 | GRIN2B | C | 0.198 | 1.78 | 0.00065 | 1.85 | 0.0051 |
| rs2160734 | GRIN2B | G | 0.488 | 0.57 | 0.00079 | 0.53 | 0.0061 |
Abbreviations: HR, hazard ratio; MAF, minor allele frequency.
Results are adjusted for recruitment site, Penn Alcohol Craving Scale and number of between last drink and initiation of acamprostate treatment. Results for the entire sample are shown along with results for the male subset