Table 4. Replication analysis using the PREDICT sample (N=110 acamprosate-treated subjects).

SNP	Gene	Minor allele	MAF	O/I	HR	P-value
rs2058878	GRIN2B	A	0.48	I	0.72	0.068
rs17035723	GLRB	T	0.18	I	0.82	0.48
rs2160733	GRIN2B	C	0.23	I	0.76	0.24
rs2160734	GRIN2B	C	0.47	O	1.31	0.13

Abbreviations: HR, hazard ratio; MAF, minor allele frequency; O/I, indicator of observed or imputed SNP; SNP, single-nucleotide polymorphism.

Results are adjusted for the Beck Depression Inventory score, age of onset of alcoholism and the number of drinks per drinking day.