Table 4.
Association of enrollment anti-DENV IgG and neutralization antibodies with incident DENV infection among 10- to 18-year-olds during the study period in Patillas, Puerto Rico in 2007 and 2008
| Enrollment specimen serology patterns | Total | Number of incident DENV infections (%) | Risk ratio | 95% CI | Rao–Scott χ2 P value |
|---|---|---|---|---|---|
| IgG anti-DENV antibodies | |||||
| No | 156 | 3 (1.5) | 1.0 | – | – |
| Yes | 152 | 16 (9.9) | 6.8 | 1.7–27.0 | < 0.008 |
| Anti-DENV neutralization antibody pattern* | |||||
| No IgG anti-DENV or neutralization antibodies | 164 | 5 (2.4) | 1.0 | – | – |
| Past DENV infection, primary DENV infections | 46 | 7 (16.2) | 6.8 | 1.7–27.0 | 0.009 |
| Past DENV infection, secondary DENV infections | 98 | 7 (6.2) | 2.6 | 0.7–9.7 | 0.14 |
Calibration weighting was applied to the calculation of all proportions, risk ratios, 95% CIs, and P values.
*
MNT was performed only on paired specimens with a positive anti-DENV IgG in either the enrollment or 12-month specimen.