Table 6. Factors affecting the diagnostic accuracy of PGD: results from simple and multiple logistic regression by using centre as a cluster factor (N=792a).
| Crude OR (95% CI) | Adjusted OR (95% CI) | |
|---|---|---|
| No. of cells used in PGD | ||
| One cell | Ref | Ref |
| Two cells | 1.66 (0.56–4.91) | 1.16 (0.46–2.92) |
| Disease category | ||
| AR | Ref | Ref |
| AD | 4.67 (1.59–13.71) | 6.31 (0.98–40.87) |
| XL-R | 2.05 (0.59–7.10) | 2.09 (0.54–8.14) |
| XL-D | 3.03 (1.04–8.87) | 3.90 (2.45–6.20) |
| PCR-PGD protocol | ||
| Multiplex | Ref | Ref |
| Singleplex | 0.80 (0.32–1.97) | 0.50 (0.13–1.94) |
| Embryo morphology | ||
| Class 1 | Ref | |
| Class 4 | 0.29 (0.04–2.23) | |
| Combined biopsy-PGD-PCR strategies | ||
| Singleplex one cell | Ref | Not includedb |
| Singleplex two cells | 1.69 (0.94–2.06) | |
| Multiplex one cell | 1.23 (0.44–3.46) | |
| Multiplex two cells | 2.19 (0.93–5.13) | |
Bold reflects statistically significant results.
a
The aberrant embryos and those whose PGD result was based on more than 2 cells were excluded from the current analysis.
b
This variable was not included in the multiple logistic regression as the number of cells and the type of PCR-PGD protocol have been included in the model as two independent variables.