Figure 13.

Intrinsically disordered FG Nups fill the NPC. Estimated abundances (numbered) and FG Nup positions in S. cerevisiae. Each FG Nup is tethered on one terminal end to the inner walls of the NPC by an anchor domain from which the remaining FG-rich domain emanates to occupy the aqueous space within the central channel. Some FG Nups are symmetric (green), while others are exclusively cytoplasmic (red) or nuclear (blue). For clarity, each FG Nup varies in length, sequence, and number/type of FG-repeats (superscript). Error bars denote uncertainty with respect to their exact anchoring sites.