Figure 5.

Crystallographic analysis of Mediator Head module. (A) Crystal structure of the Head subunits from Saccharomyces cerevisiae by Imasaki et al. at 4.3 Å resolution¹⁴⁷ and (B) crystal structure from Schizosaccharomyces pombe by Lariviere et al. at 3.9 Å resolution.¹⁴⁸ Med6 (brown), Med17 (red), Med11 (wheat), Med8 (yellow), Med18 (lime), Med20 (blue), Med22 (orange). Gaps in the structure indicate disordered regions. Names of the different domains are indicated as underscored. (C) Topological arrangements of disordered regions in the Head module: fuzzy regions, which are disordered even in the complex, are yellow; disordered regions, which fold upon interaction, are orange; and ordered protein interaction sites are blue. The ID binding site in human Med17, where L371P mutation contributes to infantile cerebral atrophy, is shown by red.