Table 1.
Summary details of the four analysis cohorts
| LBC1921 | LBC1936 | FHS | NAS | |
|---|---|---|---|---|
| N | 446 | 920 | 2,635 | 657 |
| ndeaths | 292 | 106 | 238 | 226 |
| Time to death (years) | 7.2 (3.5) | 4.4 (2.2) | 6.0 (1.2) | 10.5 (3.3) |
| Age (years) | 79.1 (0.6) | 69.5 (0.8) | 66.3 (8.9) | 72.9 (6.9) |
| Sex (male) | 176 (40%) | 465 (51%) | 1200 (46%) | 657 (100%) |
| Hannum methylation age (years) | 85.0 (5.6) | 75.8 (5.0) | 68.2 (8.7) | 77.6 (6.7) |
| Hannum Δage (years) | 5.9 (5.6) | 6.2 (5.1) | 1.9 (4.8) | 4.6 (4.8) |
| Hannum median error (years) | 5.5 | 6.4 | 1.9 | 4.6 |
| Horvath methylation age (years) | 73.7 (6.2) | 66.0 (5.8) | 65.7 (8.3) | 73.5 (7.4) |
| Horvath Δage (years) | −5.4 (6.3) | −3.6 (5.8) | −0.6 (5.2) | 0.6 (5.8) |
| Horvath median error (years) | 6.0 | 4.7 | 0.69 | 3.4 |
| Tissue sample | Whole blood | Whole blood | Whole blood | Buffy coat |
| Methylation array | Illumina 450 k | Illumina 450 k | Illumina 450 k | Illumina 450 k |
FHS: Framingham Heart Study, LBC: Lothian Birth Cohort, NAS: Normative Aging Study.