Figure 3.

Inhibition of Mcl-1 by UMI77 radiosensitizes pancreatic cancer cells. Cells were treated with UMI77 (1-3μM) as illustrated (A) and radiosensitization was assessed by clonogenic survival. Data are from a single representative experiment (B, C) or are the mean ± standard deviation/error of 2–4 independent experiments (D). Statistical significance versus control is indicated (*P<0.05). Cytotoxicity is the surviving fraction of UMI77-treated cells relative to control cells in the absence of radiation.