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UMI77 disrupts the Mcl-1/Bak complex. Panc-1 (A) and BxPC-3 (B) cells were treated with the indicated concentrations of UMI77 for 48 hours and then prepared for immunoprecipitation and immunoblotting. Mcl-1 was immunoprecipitated from cell lysates and the levels of Bak interacting with Mcl-1 were detected by immunoblotting for Bak. The levels of Bak and Mcl-1 in total cell lysates are shown (input). Data are representative of 2–3 independent experiments.
